Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.73 |
| ▸ | ERBB4 | Q15303 | 15/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240514 | 0.91 | EGFR (0.67) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7239963 | 0.87 | EGFR (0.72) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7239509 | 0.78 | EGFR (0.72) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7220144 | 0.78 | EGFR (1.00) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7116202 | 0.78 | EGFR (0.71) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7221044 | 0.76 | EGFR (0.91) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7236868 | 0.76 | ERBB2 (0.69) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7214306 | 0.76 | EGFR (0.90) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7214043 | 0.71 | EGFR (0.78) | EGFRERBB2ERBB4 | |
| SCHEMBL7233594 | 0.71 | EGFR (0.67) | EGFRERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |