Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238081 | 0.92 | GRM2 (0.41) | GRM2ACACBHRH3 | |
| SCHEMBL7229579 | 0.91 | GRM2 (0.38) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7235264 | 0.90 | GRM2 (0.38) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7227410 | 0.87 | GRM2 (0.38) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7228961 | 0.87 | GRM2 (0.39) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7235382 | 0.84 | GRM2 (0.38) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7238185 | 0.83 | MAPK1 (0.43) | GRM2PTGS2ACACBHRH3DRD4 | |
| SCHEMBL7237694 | 0.83 | ITGB3 (0.38) | GRM2PTGS2 | |
| SCHEMBL7229898 | 0.83 | GRM2 (0.38) | GRM2PTGS2ACACBDPP4FAP | |
| SCHEMBL7228827 | 0.82 | GRM2 (0.39) | GRM2PTGS2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |