Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241237 | 0.83 | KDR (0.66) | KDREGFRCA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL8040264 | 0.82 | FYN (0.53) | KDRAGERFGFR1SRCFGFR2 | |
| SCHEMBL7241137 | 0.81 | KDR (0.72) | KDREGFRCA12CA1CA2 | |
| SCHEMBL11296690 | 0.81 | KDR (1.00) | KDREGFRCA12CA1CA2 | |
| SCHEMBL7238828 | 0.77 | KDR (0.65) | KDREGFRCA12CA1CA2 | |
| SCHEMBL7230996 | 0.75 | FYN (0.68) | KDRFYNPLK1CCNA2CDK2 | |
| SCHEMBL1735288 | 0.74 | AGER (0.60) | KDRAGERFGFR1SRCFGFR2 | |
| SCHEMBL17560321 | 0.73 | KDR (0.64) | KDREGFRFYNPLK1CCNA2 | |
| SCHEMBL13377532 | 0.73 | SYK (0.53) | KDREGFRAGERFGFR1SRC | |
| SCHEMBL11297546 | 0.72 | KDR (0.75) | KDREGFRCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |