Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7240593 | 0.98 | MKNK1 (0.48) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL10475039 | 0.85 | MKNK1 (0.44) | MKNK1MKNK2CYP11B1CYP11B2TDP1 | |
| SCHEMBL30734351 | 0.84 | MKNK1 (0.46) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL8240390 | 0.84 | MKNK1 (0.46) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL17518860 | 0.83 | GSK3B (0.56) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL17819556 | 0.81 | MKNK1 (0.44) | MKNK1MKNK2CYP11B1CYP11B2TDP1 | |
| Bromide SCHEMBL17503995 | 0.81 | GSK3B (0.54) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL9448469 | 0.80 | MKNK1 (0.66) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL1863209 | 0.80 | MKNK1 (0.43) | MKNK1MKNK2MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL18246429 | 0.79 | KDM4E (0.57) | MKNK1MKNK2TDP1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242426-B1 | GAMMA-HYDROXY-2-(FLUOROALKYLAMINOCARBONYL)-1-PIPERAZINEPENTANAMIDES AS HIV PROTEASE INHIBITORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6649761-B2 | Viricides such as 4-(1-(5-(5-methoxy-3-pyridinyl)-carbonyl-methylaminocarbonyl)-1-methylethyl)-2(S)-((2,2,2-trifluoro-ethyl)aminocarbonyl)-1-(allyloxycarbonyl)piperazine and salts formed by decarboxylation using acids, then purifying | MERCK & CO., INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | MERCK & CO., INC. | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | NPEPPS, PREP, DNPEP | MKNK1 1686/4885MKNK2 1661/4885MAP4K4 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.