Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 14/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230744 | 0.89 | AAK1 (0.40) | AAK1CCR1CCR5CCR8KMO | |
| SCHEMBL7232327 | 0.88 | CCR1 (0.38) | AAK1CCR1CCR5CCR8PLAU | |
| SCHEMBL7238123 | 0.82 | ABL1 (0.35) | AAK1CCR1CCR5CCR8 | |
| SCHEMBL7846741 | 0.82 | AAK1 (0.38) | AAK1CCR1CCR5CCR8ATR | |
| SCHEMBL7229573 | 0.81 | CCR1 (0.40) | AAK1CCR1CCR5CCR8PLAU | |
| SCHEMBL7231006 | 0.79 | AAK1 (0.45) | AAK1 | |
| SCHEMBL7238064 | 0.78 | AAK1 (0.41) | AAK1 | |
| Hydrochloric Acid SCHEMBL7236046 | 0.77 | PLAU (0.55) | CCR1CCR5CCR8KMOPIK3CA | |
| SCHEMBL7238742 | 0.76 | CCR1 (0.38) | AAK1CCR1CCR5CCR8PLAU | |
| SCHEMBL7228914 | 0.75 | SIGMAR1 (0.41) | CCR1CCR5CCR8PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |