Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 7/20 | 0.44 |
| ▸ | BCR | P11274 | 7/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237026 | 0.88 | MAPT (0.45) | MAPTRAB9ANPC1ABL1BCR | |
| SCHEMBL7635971 | 0.85 | MAPT (0.46) | MAPTRAB9ANPC1ABL1BCR | |
| SCHEMBL7238638 | 0.85 | CACNA1B (0.41) | LMNASMN1; SMN2KMT2A | |
| SCHEMBL5204573 | 0.83 | EPHX2 (0.52) | MAPTRAB9ANPC1ABL1BCR | |
| SCHEMBL7235236 | 0.74 | EPHX2 (0.52) | MAPTABL1BCRPDGFRBPDGFRA | |
| SCHEMBL7236890 | 0.74 | CACNA1B (0.39) | MAPTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL7631313 | 0.73 | MAPT (0.45) | MAPTRAB9ANPC1ABL1BCR | |
| SCHEMBL5205222 | 0.71 | EPHX2 (0.48) | MAPTRAB9ANPC1ABL1BCR | |
| SCHEMBL7635766 | 0.70 | CACNA1B (0.41) | MAPTLMNASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL6986838 | 0.70 | CNR2 (0.45) | MAPTRAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627647-B1 | Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-09-30 | — | — | US | claimed |
| WO-2001070703-A2 | SUBSTITUTED 1-(4-AMINOPHENYL)IMIDAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-09-27 | — | — | WO | claimed |