Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | BCR | P11274 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7631313 | 0.88 | MAPT (0.45) | MAPTRAB9ANPC1EPHX2RXFP1 | |
| SCHEMBL5204573 | 0.86 | EPHX2 (0.52) | MAPTRAB9ANPC1EPHX2RXFP1 | |
| SCHEMBL7239115 | 0.85 | MAPT (0.46) | MAPTRAB9ANPC1RXFP1ABL1 | |
| SCHEMBL7635766 | 0.85 | CACNA1B (0.41) | MAPTLMNASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL7235236 | 0.77 | EPHX2 (0.52) | MAPTEPHX2ABL1BCRPDGFRB | |
| SCHEMBL7630028 | 0.77 | ABCB1 (0.36) | MAPTLMNAKMT2A | |
| SCHEMBL7996473 | 0.75 | USP2 (0.37) | MAPTRAB9ANPC1CYP11B1CYP11B2 | |
| SCHEMBL5205222 | 0.74 | EPHX2 (0.48) | MAPTRAB9ANPC1EPHX2RXFP1 | |
| SCHEMBL7630588 | 0.74 | TSHR (0.42) | MAPTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL7237026 | 0.73 | MAPT (0.45) | MAPTRAB9ANPC1RXFP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451820-B1 | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-09-17 | — | — | US | claimed |
| WO-2001072740-A1 | SUBSTITUTED 1-(4-AMINOPHENYL) TRIAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | claimed |