Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.60 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.60 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 11/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 11/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7238325 | 0.88 | CSNK2A2 (0.56) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL29798812 | 0.77 | TNNI3 (0.61) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL351979 | 0.77 | TNNI3 (0.61) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL7525774 | 0.71 | CSNK2A2 (0.66) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL7525776 | 0.71 | CSNK2A2 (0.97) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL11921341 | 0.71 | CSNK2A2 (0.97) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL12775846 | 0.71 | CSNK2A2 (0.66) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL11921355 | 0.69 | CSNK2A2 (0.77) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL12775843 | 0.68 | CSNK2A2 (0.57) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B | |
| SCHEMBL7526640 | 0.68 | CSNK2A2 (0.75) | TNNI3TNNT2TNNC1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630482-B1 | Cystic fibrosis | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2003-10-07 | — | — | US | disclosed |