Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.50 |
| ▸ | PLK1 | P53350 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7518134 | 0.99 | KDR (0.62) | KDRPTK2PLK1IGF1RBRAF | |
| SCHEMBL7510711 | 0.93 | KDR (0.55) | KDRPTK2PLK1IGF1RBRAF | |
| Hydrochloric Acid SCHEMBL7512667 | 0.92 | KDR (0.54) | KDRPTK2PLK1IGF1RBRAF | |
| SCHEMBL7510604 | 0.90 | KDR (0.52) | KDRPLK1IGF1RFYN | |
| Hydrochloric Acid SCHEMBL7516479 | 0.89 | KDR (0.51) | KDRPLK1IGF1RFYN | |
| SCHEMBL7241620 | 0.88 | KDR (0.70) | KDRPTK2PLK1IGF1RPDGFRB | |
| SCHEMBL7127974 | 0.85 | IGF1R (0.52) | KDRPLK1IGF1R | |
| SCHEMBL7241935 | 0.84 | KDR (0.57) | KDRPTK2IGF1RPDGFRBFYN | |
| SCHEMBL7230278 | 0.83 | KDR (0.67) | KDRPTK2PLK1IGF1RPDGFRB | |
| SCHEMBL7238442 | 0.83 | KDR (0.60) | KDRPTK2PLK1PDGFRBFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856001-B1 | PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-08-28 | — | — | EP | claimed |
| EP-0856001-A1 | PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | claimed |
| US-5753663-A | 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM | SYNTEX (U.S.A.) INC. (US) | 1998-05-19 | — | — | US | claimed |
| WO-1997012880-A1 | PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 1997-04-10 | — | — | WO | claimed |
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| EP-0856001-B1 | PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-08-28 | — | — | EP | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| EP-0856001-A1 | PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |
| US-5753663-A | 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM | SYNTEX (U.S.A.) INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997012880-A1 | PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 1997-04-10 | — | — | WO | disclosed |