Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.56 |
| ▸ | PLK1 | P53350 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241620 | 0.95 | KDR (0.70) | KDRIKBKBPTK2PLK1PDGFRB | |
| SCHEMBL8035912 | 0.89 | KDR (0.70) | KDRPTK2PLK1PDGFRBJAK2 | |
| SCHEMBL7239285 | 0.83 | KDR (0.63) | KDRPTK2PLK1PDGFRBIGF1R | |
| Hydrochloric Acid SCHEMBL7518134 | 0.83 | KDR (0.62) | KDRPTK2PLK1PDGFRBIGF1R | |
| SCHEMBL7237418 | 0.82 | FYN (0.65) | KDRIKBKBPTK2PLK1PDGFRB | |
| SCHEMBL7235444 | 0.82 | IKBKB (0.67) | KDRIKBKBPTK2PLK1PDGFRB | |
| SCHEMBL7238442 | 0.81 | KDR (0.60) | KDRIKBKBPTK2PLK1PDGFRB | |
| SCHEMBL7231942 | 0.81 | KDR (0.58) | KDRIKBKBPTK2PLK1PDGFRB | |
| Hydrochloric Acid SCHEMBL7516453 | 0.81 | IKBKB (0.66) | KDRIKBKBPTK2PLK1PDGFRB | |
| SCHEMBL7239325 | 0.81 | KDR (0.58) | KDRIKBKBPTK2PLK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |