Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.47 |
| ▸ | F10 | P00742 | 6/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228361 | 0.94 | ITGB3 (0.55) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7239022 | 0.93 | GRM2 (0.49) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7238492 | 0.92 | ITGB3 (0.50) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7237867 | 0.92 | GRM2 (0.51) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7237801 | 0.92 | ITGB3 (0.51) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7239380 | 0.90 | GRM2 (0.53) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7229693 | 0.89 | GRM2 (0.52) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL3266803 | 0.89 | GRM2 (0.52) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7227714 | 0.89 | GRM2 (0.51) | GRM2ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7228282 | 0.88 | GRM2 (0.47) | GRM2ITGB3ITGA2BPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |