Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 7/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | GPR6 | P46095 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235830 | 0.88 | CAPN1 (0.56) | CAPN1CTSSBCHETSHR | |
| SCHEMBL7238926 | 0.87 | CAPN1 (0.49) | CAPN1CTSSGPR6BCHEMAPT | |
| SCHEMBL7242368 | 0.87 | CAPN1 (0.49) | CAPN1CTSSGPR6KDM4EALOX15 | |
| SCHEMBL7241474 | 0.87 | CAPN1 (0.51) | CAPN1CTSSGPR6KDM4EALDH1A1 | |
| SCHEMBL7242371 | 0.85 | GPR6 (0.48) | CAPN1CTSSGPR6KDM4EALOX15 | |
| SCHEMBL7243236 | 0.85 | L3MBTL1 (0.49) | CAPN1CTSSGPR6MAPTTSHR | |
| SCHEMBL7238735 | 0.84 | CAPN1 (0.53) | CAPN1CTSSTSHRMEN1KMT2A | |
| SCHEMBL7242851 | 0.83 | CHIA (0.58) | CAPN1CTSSTSHR | |
| SCHEMBL7243833 | 0.82 | CAPN1 (0.69) | CAPN1CTSSKDM4EALDH1A1MAPT | |
| SCHEMBL7232336 | 0.82 | CAPN1 (0.58) | CAPN1CTSSALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |