Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 15/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 15/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 15/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 15/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467946 | 0.88 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6470205 | 0.88 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7234561 | 0.88 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6432937 | 0.86 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6436092 | 0.86 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6433267 | 0.86 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6466464 | 0.86 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7234918 | 0.85 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6431903 | 0.85 | ABCC9 (0.46) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6431863 | 0.84 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |