Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 12/20 | 0.64 |
| ▸ | MMP3 | P08254 | 5/20 | 0.64 |
| ▸ | MMP1 | P03956 | 3/20 | 0.63 |
| ▸ | MMP2 | P08253 | 3/20 | 0.63 |
| ▸ | MMP7 | P09237 | 3/20 | 0.63 |
| ▸ | MMP9 | P14780 | 3/20 | 0.63 |
| ▸ | MMP8 | P22894 | 3/20 | 0.63 |
| ▸ | MMP13 | P45452 | 3/20 | 0.63 |
| ▸ | MMP14 | P50281 | 3/20 | 0.63 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.63 |
| ▸ | MMP15 | P51511 | 1/20 | 0.57 |
| ▸ | MMP16 | P51512 | 1/20 | 0.57 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240246 | 1.00 | ADAM17 (0.64) | ADAM17MMP3MMP1MMP2MMP7 | |
| Trifluoroacetic Acid SCHEMBL7236593 | 0.96 | ADAM17 (0.60) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7232659 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7240596 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7240588 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7239421 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7239432 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7232652 | 0.90 | ADAM17 (0.65) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7233044 | 0.88 | ADAM17 (0.62) | ADAM17MMP3MMP1MMP2MMP7 | |
| SCHEMBL7233034 | 0.88 | ADAM17 (0.62) | ADAM17MMP3MMP1MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620823-B2 | Antiinflammatory agents; rheumatic disorders | BRISTOL-MYERS SQUIBB PHARME COMPANY | 2003-09-16 | — | — | US | claimed |