Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332714 | 0.92 | AURKA (0.40) | RXFP1MEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL6446798 | 0.81 | PDE5A (0.39) | MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6356420 | 0.81 | PDE5A (0.38) | RXFP1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6802097 | 0.80 | PDE5A (0.36) | RXFP1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6444767 | 0.78 | PDE5A (0.40) | MEN1KMT2AMAPK1GAAALDH1A1 | |
| SCHEMBL6442398 | 0.78 | KMT2A (0.40) | MEN1KMT2AMAPK1ALDH1A1LMNA | |
| SCHEMBL6199773 | 0.77 | HDAC1 (0.43) | MAPK1GAA | |
| SCHEMBL6200638 | 0.77 | PDE5A (0.68) | RXFP1KMT2AALDH1A1 | |
| SCHEMBL6332580 | 0.76 | PDE5A (0.57) | RXFP1KMT2AALDH1A1 | |
| SCHEMBL5827229 | 0.75 | ADRA1D (0.40) | MEN1KMT2AMAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670366-B1 | Cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors; impotence; pyrazolo(4,3-d)pyrimidin-7-ones | PFIZER INC | 2003-12-30 | — | — | US | disclosed |
| EP-0995750-A1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |