Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.61 |
| ▸ | GAK | O14976 | 5/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 5/20 | 0.53 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.53 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | STK16 | O75716 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723619 | 0.77 | GAK (0.38) | SYKGAKRIPK2COQ8ABMPR1B | |
| SCHEMBL19961847 | 0.74 | SYK (0.75) | SYKGAKRIPK2COQ8AMAP3K11 | |
| SCHEMBL16606925 | 0.73 | SYK (0.81) | SYKGAKRIPK2COQ8AMAP3K11 | |
| SCHEMBL16845897 | 0.73 | SYK (0.35) | SYKGAKRIPK2COQ8AMAP3K11 | |
| SCHEMBL10168534 | 0.70 | JAK1 (0.82) | SYKGAKRIPK2COQ8AMAP3K11 | |
| R-406 SCHEMBL1200144 | 0.69 | SYK (1.00) | SYKGAKRIPK2COQ8AMAP3K11 | |
| R-406 SCHEMBL29358236 | 0.69 | SYK (1.00) | SYKGAKRIPK2COQ8AMAP3K11 | |
| SCHEMBL15209342 | 0.69 | PTK2 (0.55) | GAKRIPK2COQ8AMAPK8MAPK9 | |
| SCHEMBL723904 | 0.69 | JAK2 (0.56) | SYKGAKRIPK2COQ8AMAP3K11 | |
| SCHEMBL725132 | 0.69 | IGF1R (0.55) | SYKGAKRIPK2COQ8AMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | claimed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | SYK, FCGRT, SSB | SYK 1/4885GAK 3176/4885RIPK2 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.