Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.51 |
| ▸ | EGFR | P00533 | 12/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244702 | 0.83 | EGFR (0.48) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7117608 | 0.82 | EGFR (0.54) | ERBB2EGFRERBB4 | |
| SCHEMBL7240463 | 0.82 | EGFR (0.55) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7234893 | 0.81 | EGFR (0.57) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7241925 | 0.81 | EGFR (0.56) | ERBB2EGFRERBB4 | |
| SCHEMBL7122314 | 0.78 | EGFR (0.54) | ERBB2EGFRERBB4 | |
| SCHEMBL7233992 | 0.74 | ERBB2 (0.47) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7236730 | 0.73 | EGFR (0.50) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7233687 | 0.72 | AURKA (0.51) | ERBB2EGFRERBB4KDR | |
| SCHEMBL7242049 | 0.72 | EGFR (0.61) | ERBB2EGFRERBB4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |