Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.67 |
| ▸ | FYN | P06241 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.53 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243671 | 0.86 | EGFR (0.71) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7239048 | 0.83 | FYN (0.85) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7235763 | 0.83 | EGFR (0.73) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7128549 | 0.81 | EGFR (0.65) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL5565146 | 0.81 | KDM4E (0.74) | EGFRERBB2FYNSRCTTBK1 | |
| SCHEMBL2985038 | 0.80 | EGFR (1.00) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL27758514 | 0.80 | FYN (0.70) | EGFRERBB2FYNSRCVCP | |
| SCHEMBL5569158 | 0.80 | ABCG2 (0.69) | EGFRERBB2ERBB4TTBK1TTBK2 | |
| SCHEMBL7243052 | 0.79 | EGFR (0.60) | EGFRERBB2ERBB4FYNSRC | |
| Hydrochloric Acid SCHEMBL8809726 | 0.79 | ABCG2 (0.68) | EGFRERBB2ERBB4TTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |