Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.71 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.54 |
| ▸ | GMPS | P49915 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237773 | 0.92 | KDR (0.60) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7243449 | 0.88 | EGFR (0.70) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7235763 | 0.88 | EGFR (0.73) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7234949 | 0.87 | EGFR (0.67) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7242579 | 0.86 | EGFR (0.67) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7239590 | 0.85 | EGFR (0.56) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7239977 | 0.83 | EGFR (1.00) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7235194 | 0.82 | EGFR (0.80) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7235049 | 0.82 | EGFR (0.79) | EGFRERBB2ERBB4KDRTEK | |
| SCHEMBL7235041 | 0.82 | EGFR (0.79) | EGFRERBB2ERBB4KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |