Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15903899 | 1.00 | RNPEP (0.47) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL30975661 | 0.82 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL771623 | 0.82 | FOLH1 (0.38) | RNPEPLMNAALDH1A1KDM4EFOLH1 | |
| SCHEMBL164056 | 0.82 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL748892 | 0.82 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL76427 | 0.82 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Iodide SCHEMBL3658380 | 0.80 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrogen Sulfide SCHEMBL1498068 | 0.80 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL7204481 | 0.80 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrogen Sulfide SCHEMBL11572294 | 0.80 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541491-B1 | Treating ras mediated diseases, especially cancer. | ZENECA LIMITED (GB) | 2003-04-01 | — | — | US | disclosed |
| US-6232338-B1 | 4-Mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |
| EP-0842151-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006138-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1997-02-20 | — | — | WO | disclosed |