Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.44 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3348587 | 1.00 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL232286 | 0.98 | RNPEP (0.48) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL349508 | 0.98 | RNPEP (0.48) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL76427 | 0.98 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL164056 | 0.98 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL748892 | 0.98 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| SCHEMBL30975661 | 0.98 | RNPEP (0.52) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrogen Sulfide SCHEMBL1498068 | 0.96 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Hydrogen Sulfide SCHEMBL1498065 | 0.96 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E | |
| Iodide SCHEMBL3658380 | 0.96 | RNPEP (0.50) | RNPEPLMNAALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107459473-B | A kind of methionine derivative corrosion inhibiter and its synthetic method for pickling iron and steel | 唐山学院 | 2019-02-01 | — | — | CN | claimed |
| CN-107459473-A | A kind of methionine derivative corrosion inhibiter and its synthetic method for pickling iron and steel | 唐山学院 | 2017-12-12 | — | — | CN | claimed |
| CN-117447373-A | Preparation of methionine derivative and its salts and use as antibacterial agent | 黑龙江八一农垦大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-115043765-B | Preparation of methionine derivative and its salt and use as gene carrier | 黑龙江八一农垦大学 | 2023-08-15 | — | — | CN | disclosed |
| CN-116253671-A | Cannabidiol derivative and preparation method and application thereof | 德义制药有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-114181150-A | Pyrazole amide derivative, preparation method and application thereof | 沈阳万菱生物技术有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-112778167-A | Method for rapidly preparing N-benzenesulfonyl amino acid ester compound | 邵阳学院 | 2021-05-11 | — | — | CN | disclosed |
| CN-111264859-A | Preparation process of purple cabbage fermentation concentrated powder | 台健生物科技(福建)有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-107459473-B | A kind of methionine derivative corrosion inhibiter and its synthetic method for pickling iron and steel | 唐山学院 | 2019-02-01 | — | — | CN | disclosed |
| CN-108117580-A | Sarsasapogenin derivative and its preparation method and application | 沈阳药科大学 | 2018-06-05 | — | — | CN | disclosed |
| CN-107459473-A | A kind of methionine derivative corrosion inhibiter and its synthetic method for pickling iron and steel | 唐山学院 | 2017-12-12 | — | — | CN | disclosed |
| CN-1186332-C | Novel thyroid receptor ligands and method II | KAROBIO AB (SE) | 2005-01-26 | — | — | CN | disclosed |
| EP-0894010-B1 | DENATURANTS FOR SYMPATHOMIMETIC AMINE SALTS | WARNER LAMBERT CO (US) | 2003-07-02 | — | — | EP | disclosed |
| CN-1337953-A | Novel thyroid receptor ligands and method II | KAROBIO AB (SE) | 2002-02-27 | — | — | CN | disclosed |
| US-6136864-A | MIXTURE OF GUM AND SURFACTANT; SUSTAINED RELEASE | WARNER-LAMBERT COMPANY (US) | 2000-10-24 | — | — | US | disclosed |
| EP-0894010-A2 | DENATURANTS FOR SYMPATHOMIMETIC AMINE SALTS | Warner-Lambert Company LLC (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997037689-A2 | DENATURANTS FOR SYMPATHOMIMETIC AMINE SALTS | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | disclosed |
| CN-1151156-A | Isoprenyl transferase inhibitors | EISAI CO LTD (JP) | 1997-06-04 | — | — | CN | disclosed |
| CN-1098408-A | The heterocycle inhibitor of farnesyl-protein transferase | BRISTOL MYERS SQIBB COMPANY (US) | 1995-02-08 | — | — | CN | disclosed |
| CN-1048703-A | Novel propylene acid amides, its preparation method, contain the pharmaceutical preparation of this composition and the application in medicine thereof | RICHTER GEDEON VEGYESZET (HU) | 1991-01-23 | — | — | CN | disclosed |