Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.64 |
| ▸ | FYN | P06241 | 7/20 | 0.58 |
| ▸ | SRC | P12931 | 7/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.58 |
| ▸ | BLK | P51451 | 1/20 | 0.58 |
| ▸ | BMX | P51813 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233748 | 0.93 | EGFR (0.60) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL8156590 | 0.81 | EGFR (0.47) | EGFRERBB2FYNSRC | |
| SCHEMBL2994028 | 0.79 | EGFR (1.00) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL31605602 | 0.79 | EGFR (1.00) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL7237990 | 0.78 | EGFR (0.44) | EGFRERBB2SRC | |
| SCHEMBL8490631 | 0.77 | EGFR (0.55) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL7237992 | 0.77 | EGFR (0.44) | EGFRERBB2 | |
| SCHEMBL2986894 | 0.76 | EGFR (1.00) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL7127185 | 0.75 | EGFR (1.00) | EGFRERBB2FYNSRCERBB4 | |
| Hydrochloric Acid SCHEMBL3000541 | 0.75 | EGFR (0.98) | EGFRERBB2FYNSRCERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |