Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233748 | 0.86 | EGFR (0.60) | EGFRERBB2ERBB3DUS2FYN | |
| SCHEMBL7237990 | 0.81 | EGFR (0.44) | EGFRERBB2SRCKDR | |
| SCHEMBL7243799 | 0.81 | EGFR (0.64) | EGFRERBB2FYNSRC | |
| SCHEMBL7237992 | 0.81 | EGFR (0.44) | EGFRERBB2KDR | |
| SCHEMBL8490303 | 0.74 | EGFR (0.47) | EGFRERBB2ERBB3DUS2KDM4E | |
| SCHEMBL4187418 | 0.73 | EGFR (0.69) | EGFRERBB2FYNSRC | |
| SCHEMBL8149145 | 0.72 | EGFR (0.66) | EGFRERBB2CSF1RFYNSRC | |
| SCHEMBL8143063 | 0.69 | EGFR (0.68) | EGFRERBB2MEN1MAPTKMT2A | |
| SCHEMBL8486257 | 0.68 | RAF1 (0.55) | EGFRERBB2MAPTFYNSRC | |
| SCHEMBL8486248 | 0.68 | EGFR (0.52) | EGFRERBB2MAPTFYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |