Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452474 | 0.85 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5453721 | 0.79 | MAPK14 (0.50) | KDRMAPK9EGFRRAF1ERBB2 | |
| SCHEMBL14519560 | 0.77 | HRH3 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5447721 | 0.77 | MAP4K4 (0.48) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL5463476 | 0.76 | SIGMAR1 (0.40) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL5453641 | 0.76 | KDM4E (0.45) | MAPK14 | |
| SCHEMBL7151203 | 0.76 | MAPK14 (0.52) | KDRMAPK9EGFRRAF1ERBB2 | |
| SCHEMBL14521999 | 0.74 | MAPK14 (0.54) | EGFRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5452518 | 0.72 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11CSNK2A1 | |
| SCHEMBL27540765 | 0.72 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617324-B1 | Phenyl, cyclohexyl and pyridinyl or pyrimidinyl-substituted | G. D. SEARLE & COMPANY | 2003-09-09 | — | — | US | disclosed |