Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 19/20 | 0.54 |
| ▸ | HRH1 | P35367 | 19/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250665 | 1.00 | HRH2 (0.54) | HRH2HRH1HRH3 | |
| SCHEMBL7252080 | 0.94 | HRH2 (0.52) | HRH2HRH1HRH3 | |
| SCHEMBL7252070 | 0.94 | HRH2 (0.52) | HRH2HRH1HRH3 | |
| SCHEMBL7247088 | 0.89 | HRH2 (0.59) | HRH2HRH1HRH3 | |
| SCHEMBL7245540 | 0.89 | HRH2 (0.59) | HRH2HRH1HRH3 | |
| SCHEMBL7246172 | 0.85 | HRH2 (0.74) | HRH2HRH1HRH3 | |
| SCHEMBL7250277 | 0.83 | HRH2 (0.72) | HRH2HRH1HRH3 | |
| SCHEMBL7243633 | 0.82 | HRH2 (0.72) | HRH2HRH1HRH3 | |
| SCHEMBL7245313 | 0.79 | HRH2 (0.70) | HRH2HRH1HRH3 | |
| SCHEMBL7251251 | 0.79 | HRH2 (0.72) | HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030100549-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-29 | — | — | US | disclosed |
| US-6559140-B2 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | ABBOTT LABORATORIES | 2003-05-06 | — | — | US | disclosed |
| US-20010049367-A1 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | ABBVIE INC. | 2001-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049367-A1 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | HRH4, HRH2, HRH3 | HRH2 2/4885HRH1 4/4885HRH3 3/4885 |
| US-20030100549-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | MAP3K1, JUN, MAP3K7 | HRH2 3358/4885HRH1 3790/4885HRH3 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.