Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 7/20 | 0.42 |
| ▸ | CDC25B | P30305 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106435 | 1.00 | LSS (0.49) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL30106436 | 1.00 | LSS (0.49) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL11418481 | 1.00 | LSS (0.49) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL29637459 | 0.90 | NR1I2 (0.49) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL28208065 | 0.90 | NR1I2 (0.49) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL29440355 | 0.87 | NR1H4 (0.48) | LSSNR1I2NR1H4RORCCDC25A | |
| SCHEMBL30106433 | 0.87 | NR1I2 (0.62) | LSSNR1I2NR1H4RORCMEN1 | |
| SCHEMBL16752069 | 0.87 | NR1I2 (0.62) | LSSNR1I2NR1H4RORCMEN1 | |
| SCHEMBL31274337 | 0.87 | NR1I2 (0.62) | LSSNR1I2NR1H4RORCMEN1 | |
| SCHEMBL9347158 | 0.86 | NR1I2 (0.52) | LSSNR1I2NR1H4RORCCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9427431-B2 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-08-30 | — | — | US | disclosed |
| US-20120183603-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-07-19 | — | — | US | disclosed |
| US-20030004148-A1 | Regulation of meiosis | NOVO NORDISK A/S (DK) | 2003-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183603-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | LSS 1528/4885NR1I2 1410/4885NR1H4 104/4885 |
| US-20030004148-A1 | Regulation of meiosis | ALPG, MNS1, BUB1B | LSS 1593/4885NR1I2 596/4885NR1H4 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.