Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249743 | 0.92 | F2 (0.53) | F2HDAC6ITK | |
| SCHEMBL7245893 | 0.91 | F2 (0.53) | F2HDAC6HDAC1ITKHDAC8 | |
| SCHEMBL7248824 | 0.91 | F2 (0.54) | F2HDAC6HDAC1ITKHDAC8 | |
| SCHEMBL7245229 | 0.91 | F2 (0.53) | F2HDAC6HDAC1ITKHDAC8 | |
| SCHEMBL7245210 | 0.90 | F2 (0.51) | F2MEN1KMT2AHDAC6HDAC1 | |
| SCHEMBL7244643 | 0.89 | F2 (0.50) | F2MEN1NPC1KMT2AHDAC6 | |
| SCHEMBL6781239 | 0.89 | F2 (0.57) | F2HDAC6HDAC1ITKHDAC8 | |
| SCHEMBL7244700 | 0.88 | F2 (0.48) | F2MEN1KMT2AHDAC6HDAC1 | |
| SCHEMBL6781282 | 0.87 | F2 (0.55) | F2MEN1NPC1KMT2AHDAC6 | |
| SCHEMBL6781471 | 0.87 | F2 (0.62) | F2MEN1NPC1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |