Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244643 | 0.94 | F2 (0.50) | F2HDAC1HDAC8FNTAFNTB | |
| SCHEMBL7245646 | 0.90 | F2 (0.63) | F2HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL7245590 | 0.88 | CNR2 (0.45) | F2BCHEACHECNR1CNR2 | |
| SCHEMBL7249769 | 0.87 | HSD17B10 (0.47) | F2FNTAFNTBITK | |
| SCHEMBL7245070 | 0.87 | F2 (0.53) | F2HDAC1HDAC8FNTAFNTB | |
| SCHEMBL7244700 | 0.87 | F2 (0.48) | F2HDAC1HDAC8CNR1CNR2 | |
| SCHEMBL7245916 | 0.86 | F2 (0.46) | F2HDAC1FNTAFNTBCNR1 | |
| SCHEMBL7245893 | 0.85 | F2 (0.53) | F2HDAC1HDAC8FNTAFNTB | |
| SCHEMBL7246953 | 0.84 | F2 (0.46) | F2HDAC1HDAC8BCHEACHE | |
| SCHEMBL7245229 | 0.84 | F2 (0.53) | F2HDAC1HDAC8HDAC6ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |