⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL150687 | 0.78 | — | — | |
| SCHEMBL6240800 | 0.76 | — | — | |
| SCHEMBL4864412 | 0.76 | — | — | |
| SCHEMBL6466885 | 0.76 | — | — | |
| SCHEMBL30888429 | 0.75 | CCR1 (0.40) | — | |
| SCHEMBL28288104 | 0.75 | CCR1 (0.40) | — | |
| SCHEMBL17799 | 0.73 | — | — | |
| SCHEMBL4135195 | 0.73 | HRH3 (0.34) | — | |
| SCHEMBL17247611 | 0.73 | PIK3CA (0.37) | — | |
| SCHEMBL1092283 | 0.73 | P4HTM (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003862-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| US-6544986-B2 | Such as 5-(N,N-dibenzyl)aminocarbonyl-2-pyridone; enzyme inhibitors; for treatment of Alzheimer's disease | DALHOUSIE UNIVERSITY (CA) | 2003-04-08 | — | — | US | disclosed |
| US-6436972-B1 | HETEROCYCLIC AMIDES, USED AS ANTICHOLINERGICS AND SERINE PROTEASE STIMULANTS, FOR PROPHYLAXIS OF ALZHEIMER'S DISEASE, GLIOMAS AND VISION DEFECTS | DALHOUSIE UNIVERSITY (CA) | 2002-08-20 | — | — | US | disclosed |
| US-20020049330-A1 | Novel pyridones and their use as modulators of serine hydrolase enzymes | DALHOUSIE UNIVERSITY | 2002-04-25 | — | — | US | disclosed |
| WO-2001077078-A1 | NOVEL PYRIDONES AND THEIR USE AS MODULATORS OF SERINE HYDROLASE ENZYMES | DALHOUSIE UNIVERSITY (CA) | 2001-10-18 | — | — | WO | disclosed |
| EP-0558022-B1 | Process for preparing 3-cyano-6-hydroxypyridine | MITSUBISHI CHEM CORP (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-5436145-A | REACTING 3-CYANOPYRIDINE WITH A MICROORGANISM OR AN EXTRACT THEREOF IN AN AQUEOUS MEDIUM | MITSUBISHI KASEI CORPORATION (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0558022-A2 | Process for preparing 3-cyano-6-hydroxypyridine | Mitsubishi Chemical Corporation (JP) | 1993-09-01 | — | — | EP | disclosed |