Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367888 | 0.82 | NPC1 (0.48) | NPC1RAB9APOLBKMT2AKDM1A | |
| SCHEMBL7072559 | 0.80 | KMT2A (0.47) | POLBKMT2AKDM1ADAO | |
| SCHEMBL7243797 | 0.80 | PPARG (0.39) | NPC1RAB9AKMT2A | |
| SCHEMBL663 | 0.79 | POLB (0.47) | POLBKMT2AKDM1ADAO | |
| SCHEMBL7295324 | 0.79 | DAO (0.47) | NPC1RAB9APOLBKMT2AKDM1A | |
| SCHEMBL4672103 | 0.77 | OXER1 (0.52) | KMT2A | |
| SCHEMBL9105728 | 0.76 | NPC1 (0.53) | NPC1RAB9APOLB | |
| SCHEMBL6942314 | 0.76 | DAO (0.45) | NPC1RAB9APOLBKMT2AKDM1A | |
| SCHEMBL26513551 | 0.76 | KDM1A (0.46) | NPC1RAB9APOLBKMT2AKDM1A | |
| SCHEMBL28223276 | 0.76 | OXER1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503907-B2 | Indole derivatives or dihydroindole derivatives or salts are useful for the treatment of diseases associated with 2,3-oxidosqualene-lanosterol cyclase such as gallstone, tumorhypercholesterolemia, hyperlipemia, arterioscerosis etc. | HOFFMANN-LA ROCHE INC. | 2003-01-07 | — | — | US | disclosed |