Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603605 | 0.80 | PPARG (0.45) | PPARGAGTR1AGTR2TSHRCA12 | |
| SCHEMBL7246243 | 0.80 | NPC1 (0.49) | KMT2ARAB9ANPC1 | |
| SCHEMBL11375360 | 0.80 | PPARG (0.40) | PPARGAGTR1AGTR2KMT2AALDH1A1 | |
| SCHEMBL11504340 | 0.79 | HTT (0.42) | PPARGKMT2AALDH1A1MEN1USP2 | |
| SCHEMBL7243803 | 0.77 | HPGD (0.46) | KMT2AALDH1A1GLATSHRCASP7 | |
| SCHEMBL11390081 | 0.76 | CA12 (0.43) | PPARGAGTR1AGTR2KMT2AALDH1A1 | |
| SCHEMBL28206798 | 0.76 | CA12 (0.40) | PPARGKMT2AALDH1A1MEN1USP2 | |
| SCHEMBL11389628 | 0.76 | HTT (0.43) | KMT2AALDH1A1MEN1USP2TSHR | |
| SCHEMBL11396410 | 0.76 | CA12 (0.40) | PPARGAGTR1AGTR2KMT2AALDH1A1 | |
| SCHEMBL13307121 | 0.75 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1TSHRMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503907-B2 | Indole derivatives or dihydroindole derivatives or salts are useful for the treatment of diseases associated with 2,3-oxidosqualene-lanosterol cyclase such as gallstone, tumorhypercholesterolemia, hyperlipemia, arterioscerosis etc. | HOFFMANN-LA ROCHE INC. | 2003-01-07 | — | — | US | disclosed |