Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 17/20 | 0.66 |
| ▸ | EDNRA | P25101 | 17/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.65 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252243 | 0.92 | EDNRB (0.70) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL7246411 | 0.79 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL20769813 | 0.79 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL138157 | 0.79 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL3679 | 0.79 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL3023434 | 0.79 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL7252610 | 0.77 | EDNRB (0.90) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL7246327 | 0.77 | EDNRB (0.90) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL7230664 | 0.76 | EDNRB (0.78) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL7231048 | 0.75 | EDNRB (0.69) | EDNRBEDNRANR1I2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670367-B1 | Vasodilator; hypertension; surprisingly show antagonistic action on the neurokinin receptor; 2-(4-Methoxy-6-methyl-2-pyrimidinyloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionic Acid | ABBOTT GMBH & CO., KG (DE) | 2003-12-30 | — | — | US | disclosed |