Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246399 | 0.99 | TDP1 (0.49) | TDP1TSHRKDM4ESMN1; SMN2DRD2 | |
| SCHEMBL7236660 | 0.90 | TDP1 (0.46) | TDP1KDM4EDRD3ALDH1A1MEN1 | |
| SCHEMBL7239573 | 0.84 | KDM4E (0.49) | TDP1TSHRKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15174765 | 0.71 | GRM5 (0.52) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL9183816 | 0.70 | TSHR (0.54) | TDP1TSHRKDM4ESMN1; SMN2DRD2 | |
| SCHEMBL14397182 | 0.69 | TSHR (0.67) | TDP1TSHRKDM4ESMN1; SMN2DRD2 | |
| SCHEMBL17808861 | 0.69 | ALDH1A1 (0.55) | TSHRKDM4ESMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13050024 | 0.68 | KDM4E (0.69) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11029813 | 0.68 | TDP1 (0.48) | TDP1TSHRDRD2DRD1DRD3 | |
| SCHEMBL29573150 | 0.67 | TDP1 (0.66) | TDP1TSHRKDM4ESMN1; SMN2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114449-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2003-06-19 | — | — | US | claimed |
| EP-1255756-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2002-11-13 | — | — | EP | claimed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | claimed |
| US-20030114449-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2003-06-19 | — | — | US | disclosed |
| EP-1255756-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |