Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247440 | 1.00 | L3MBTL1 (0.51) | L3MBTL1CYP19A1CREBBPSCDSCD5 | |
| SCHEMBL2413457 | 0.75 | L3MBTL1 (0.62) | L3MBTL1CYP19A1CREBBPMPOADORA2A | |
| SCHEMBL51254 | 0.74 | SLC6A2 (0.50) | TDP1 | |
| SCHEMBL2186411 | 0.74 | SLC6A2 (0.50) | TDP1 | |
| SCHEMBL873444 | 0.74 | SLC6A2 (0.50) | TDP1 | |
| SCHEMBL19948883 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CYP19A1CREBBPMPOADORA2A | |
| SCHEMBL10085530 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CYP19A1CREBBPMAPTMPO | |
| SCHEMBL1244019 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CYP19A1CREBBPMPOADORA2A | |
| Hydrochloric Acid SCHEMBL3763491 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CYP19A1CREBBPMAPTMPO | |
| SCHEMBL9908393 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CYP19A1CREBBPSCDSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617347-B1 | Substituted pyrazoles are treatment of Type II diabetes and obesity. | ELI LILLY AND COMPANY | 2003-09-09 | — | — | US | disclosed |
| US-6232337-B1 | USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY | 2001-05-15 | — | — | US | disclosed |
| US-6046227-A | USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY; A SUBSTITUTED PYRAZINE COMPOUND | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999029673-A1 | SELECTIVE β3 ADRENERGIC AGONISTS | ELI LILLY AND COMPANY (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0921120-A1 | Selective beta 3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |