Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 20/20 | 0.61 |
| ▸ | MMP13 | P45452 | 11/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340424 | 0.87 | MMP12 (0.80) | MMP12MMP13 | |
| SCHEMBL3072855 | 0.86 | MMP12 (0.56) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3072856 | 0.86 | MMP12 (0.56) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010044 | 0.86 | MMP12 (0.66) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4011261 | 0.86 | MMP12 (0.66) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010042 | 0.86 | MMP12 (0.66) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3080871 | 0.84 | MMP12 (0.66) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3086481 | 0.84 | MMP12 (0.58) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3086479 | 0.84 | MMP12 (0.58) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3081334 | 0.84 | MMP12 (0.61) | MMP12MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624177-B1 | Treating diseases in which matrix melatoproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital | WARNER-LAMBERT COMPANY | 2003-09-23 | — | — | US | disclosed |