Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 5/20 | 0.36 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242820 | 0.85 | HRH3 (0.40) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7243888 | 0.83 | HTR7 (0.40) | HRH3HTR7CYP19A1TAS2R14HRH2 | |
| SCHEMBL7246880 | 0.83 | HRH2 (0.37) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7248526 | 0.83 | NSD2 (0.40) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7246992 | 0.82 | HRH2 (0.38) | HRH3HTR7CYP19A1TAS2R14HRH2 | |
| SCHEMBL7243646 | 0.82 | HRH3 (0.38) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7244738 | 0.81 | HTR7 (0.41) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL6095376 | 0.81 | HRH3 (0.46) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7245472 | 0.81 | KDM1A (0.37) | HRH3HTR7CYP19A1HRH2HRH1 | |
| SCHEMBL7243503 | 0.80 | HRH3 (0.42) | HRH3HRH2HRH1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |