Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989424 | 0.81 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5898316 | 0.68 | BCHE (0.45) | GPR119 | |
| SCHEMBL31499335 | 0.67 | BCHE (0.42) | GPR119SCN9A | |
| SCHEMBL31499325 | 0.66 | BCHE (0.40) | GPR119 | |
| SCHEMBL18025768 | 0.65 | BCHE (0.49) | GPR119 | |
| SCHEMBL4985870 | 0.65 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4989336 | 0.65 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4994073 | 0.65 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31499348 | 0.64 | BCHE (0.40) | GPR119 | |
| SCHEMBL7567891 | 0.64 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632811-B2 | Administering cycloalkyl, lactam, lactone compounds for for inhibiting beta -amyloid peptide release and/or its synthesis in a cell | ATHENA NEUROSCIENCES, INC. | 2003-10-14 | — | — | US | disclosed |