Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | GFER | P55789 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27927838 | 0.84 | MAPT (0.79) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL19221483 | 0.83 | L3MBTL1 (0.57) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL6002470 | 0.81 | MAPT (0.73) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL21904781 | 0.80 | BCL6 (0.60) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL28992855 | 0.80 | MAPT (0.54) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL4626757 | 0.79 | HSD17B10 (0.75) | MAPTKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL7708956 | 0.79 | MAPT (0.63) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL28992860 | 0.79 | MAPT (0.53) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL2614942 | 0.76 | TDP1 (0.58) | MAPTKMT2ATDP1MEN1GFER | |
| SCHEMBL30692252 | 0.76 | TDP1 (0.58) | MAPTKMT2ATDP1MEN1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617453-B1 | Preparing these triphendioxazine compounds by a cyclization step conducted in the presence of manganese dioxide and concentrated sulphuric acid. | CLARIANT FINANCE (BVI) LIMITED (VG) | 2003-09-09 | — | — | US | disclosed |