Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | VHL | P40337 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 2/20 | 0.30 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.30 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7160547 | 0.99 | MC3R (0.33) | MC3RMC1RMEN1USP2LMNA | |
| SCHEMBL7139402 | 0.88 | PTGER4 (0.36) | MC3RMC1RMEN1USP2LMNA | |
| SCHEMBL7247787 | 0.87 | F2 (0.35) | MC3RMC1RNPSR1F2XIAP | |
| SCHEMBL7465555 | 0.87 | MC3R (0.31) | MC3RMC1RNPSR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7158175 | 0.86 | F2 (0.36) | MC3RMC1RNPSR1F2XIAP | |
| Hydrochloric Acid SCHEMBL7156752 | 0.86 | MC3R (0.31) | MC3RMC1RNPSR1 | |
| SCHEMBL7252651 | 0.82 | NPSR1 (0.32) | MC3RMC1RMEN1USP2LMNA | |
| SCHEMBL7143011 | 0.81 | F2 (0.35) | MEN1USP2LMNAACEKMT2A | |
| SCHEMBL7249630 | 0.81 | NPC1 (0.30) | KMT2A | |
| SCHEMBL7148085 | 0.81 | CTSD (0.33) | MEN1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552038-B1 | For use as thrombin inhibitors, coagulation inhibitors and agents for therapy of thromboembolic disorders | ELI LILLY AND COMPANY | 2003-04-22 | — | — | US | claimed |
| EP-0816376-B1 | Trombin inhibitors as anticoagulant agents | LILLY CO ELI (US) | 2002-11-06 | — | — | EP | claimed |
| EP-0816376-A1 | Trombin inhibitors as anticoagulant agents | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | claimed |