Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.73 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | GSK3A | P49840 | 3/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400397 | 0.92 | GSK3B (0.84) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7255498 | 0.90 | GSK3B (0.72) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5100089 | 0.90 | GSK3B (0.69) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5092053 | 0.90 | GSK3B (0.69) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5092295 | 0.87 | GSK3B (0.57) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7249883 | 0.85 | GSK3B (0.54) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4391839 | 0.84 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5091606 | 0.84 | GSK3B (0.73) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL29357223 | 0.84 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL29381876 | 0.84 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2003-07-10 | — | — | US | disclosed |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | GSK3B 1/4885CDK1 7/4885GSK3A 2/4885 |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | GSK3B 1/4885CDK1 7/4885GSK3A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.