Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.43 |
| ▸ | MMP2 | P08253 | 11/20 | 0.39 |
| ▸ | MMP3 | P08254 | 10/20 | 0.39 |
| ▸ | MMP7 | P09237 | 10/20 | 0.39 |
| ▸ | MMP1 | P03956 | 9/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.37 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248308 | 1.00 | APP (0.43) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL7248694 | 0.94 | NOTCH1 (0.43) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL7246639 | 0.78 | FPR2 (0.43) | — | |
| SCHEMBL7247071 | 0.71 | APP (0.45) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL4490715 | 0.69 | APP (0.68) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL8241343 | 0.68 | NOTCH1 (0.53) | MMP2MMP3MMP7MMP1MMP8 | |
| SCHEMBL7253237 | 0.67 | TACR1 (0.42) | — | |
| SCHEMBL4499276 | 0.67 | NOTCH1 (0.50) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL7247698 | 0.67 | APP (0.48) | APPMMP2MMP3MMP7MMP1 | |
| SCHEMBL4485658 | 0.66 | APP (0.58) | APPMMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525044-B2 | Treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome. | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-25 | — | — | US | disclosed |
| US-20020055501-A1 | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055501-A1 | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production | APP, APH1A, APH1B | APP 1/4885MMP2 3800/4885MMP3 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.