Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.38 |
| ▸ | CASK | O14936 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146175 | 0.85 | MET (0.54) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL7250921 | 0.78 | KDR (0.47) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL7251362 | 0.78 | KDR (0.48) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL7251716 | 0.77 | MET (0.49) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL7125587 | 0.77 | KDR (0.65) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL144583 | 0.75 | MET (0.63) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL142117 | 0.75 | MET (0.63) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL7252892 | 0.75 | MET (0.49) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL141818 | 0.75 | KDR (0.67) | METKDRMEN1KMT2ACDK2 | |
| SCHEMBL145802 | 0.75 | KDR (0.62) | METKDRMEN1KMT2ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | claimed |