⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15601308 | 0.80 | — | — | |
| SCHEMBL1286847 | 0.79 | ARG1 (0.33) | — | |
| SCHEMBL23628749 | 0.76 | — | — | |
| SCHEMBL25679409 | 0.76 | — | — | |
| SCHEMBL15296979 | 0.76 | — | — | |
| SCHEMBL13713539 | 0.71 | — | — | |
| SCHEMBL18477434 | 0.71 | — | — | |
| SCHEMBL23339265 | 0.71 | — | — | |
| SCHEMBL9566472 | 0.68 | — | — | |
| SCHEMBL22871574 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973407-B1 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | CHEN GUOQING PAUL | 2011-09-29 | — | — | US | disclosed |
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | CHEN GUOQING PAUL | 2011-09-29 | — | — | US | disclosed |
| US-7977346-B2 | Spiro compounds and methods of use | CHEN GUOQING PAUL | 2011-07-12 | — | — | US | disclosed |
| US-7977346-B2 | Spiro compounds and methods of use | CHEN GUOQING PAUL | 2011-07-12 | — | — | US | disclosed |
| WO-2007084875-A2 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | disclosed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | disclosed |
| WO-2003014108-A1 | NEW QUINOLINE CARBOXYLIC ACID DERIVATIVES SUBSTITUTED BY 7-(AMINOMETHYL-5-AZOSPIRO[2,4]HEPTANE) AND THEIR PREPARTION METHOD | INSTITUTE OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-02-20 | — | — | WO | disclosed |