Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | SYK | P43405 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258386 | 0.92 | KDR (0.58) | KDRSYKNPC1RAB9ATNIK | |
| SCHEMBL15358459 | 0.79 | KDR (0.61) | KDRSYKNPC1RAB9AROCK1 | |
| SCHEMBL15349630 | 0.78 | KDR (0.60) | KDRSYKNPC1RAB9AROCK1 | |
| SCHEMBL3758727 | 0.75 | ROCK2 (0.61) | KDRSYKNPC1ROCK1ROCK2 | |
| SCHEMBL7253695 | 0.72 | NPC1 (0.54) | KDRSYKNPC1RAB9ATNIK | |
| SCHEMBL32671630 | 0.71 | CHEK1 (0.61) | KDRSYKNPC1RAB9ACHEK1 | |
| SCHEMBL32671631 | 0.71 | CHEK1 (0.61) | KDRSYKNPC1RAB9ACHEK1 | |
| SCHEMBL32671628 | 0.71 | CHEK1 (0.61) | KDRSYKNPC1RAB9ACHEK1 | |
| SCHEMBL6639550 | 0.71 | SYK (0.53) | KDRSYKNPC1RAB9AROCK1 | |
| SCHEMBL5318416 | 0.71 | TNIK (0.60) | KDRSYKNPC1RAB9ATNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003030909-A1 | 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |