Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 17/20 | 1.00 |
| ▸ | EDNRA | P25101 | 17/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.62 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252610 | 0.95 | EDNRB (0.90) | EDNRBEDNRAKMT2APOLBRAB9A | |
| SCHEMBL7246781 | 0.93 | EDNRB (0.86) | EDNRBEDNRA | |
| SCHEMBL27499036 | 0.92 | EDNRB (0.85) | EDNRBEDNRAKMT2APOLBRAB9A | |
| SCHEMBL7250687 | 0.92 | EDNRB (0.89) | EDNRBEDNRAKMT2APOLBRAB9A | |
| SCHEMBL7246411 | 0.88 | EDNRB (1.00) | EDNRBEDNRAKMT2APOLBRAB9A | |
| SCHEMBL7247224 | 0.88 | EDNRB (0.89) | EDNRBEDNRAKMT2A | |
| SCHEMBL7245599 | 0.87 | EDNRB (0.80) | EDNRBEDNRAKMT2A | |
| SCHEMBL7245146 | 0.86 | EDNRB (0.88) | EDNRBEDNRAKMT2A | |
| SCHEMBL7248184 | 0.86 | EDNRB (0.90) | EDNRBEDNRA | |
| SCHEMBL7253872 | 0.86 | EDNRB (0.75) | EDNRBEDNRAKMT2APOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670367-B1 | Vasodilator; hypertension; surprisingly show antagonistic action on the neurokinin receptor; 2-(4-Methoxy-6-methyl-2-pyrimidinyloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionic Acid | ABBOTT GMBH & CO., KG (DE) | 2003-12-30 | — | — | US | disclosed |
| EP-0929529-A2 | AZINYLOXY, AND PHENOXY-DIARYL-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS MIXED ET A?/ET B? ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998009953-A2 | AZINYLOXY-AND PHENOXY-DIARYL-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS MIXED ETA/ETB ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-12 | — | — | WO | disclosed |