Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.45 |
| ▸ | IDH1 | O75874 | 2/20 | 0.45 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537566 | 0.81 | MAPK1 (1.00) | MAPK1MAPTESR2GPR119NR1H2 | |
| SCHEMBL725593 | 0.80 | IDH1 (0.40) | MAPK1IDH1 | |
| SCHEMBL724954 | 0.80 | MAPK1 (0.54) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL3263460 | 0.80 | MAPT (0.61) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL29462394 | 0.80 | MAPT (0.61) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL12162569 | 0.78 | MAPK1 (0.53) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL29814602 | 0.77 | MAPT (0.56) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL20364360 | 0.77 | MAPT (0.56) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL2113016 | 0.77 | MAPK1 (0.53) | MAPK1POLBMAPTESR2GPR119 | |
| SCHEMBL2209530 | 0.75 | IDH1 (0.52) | MAPK1POLBMAPTGPR119IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2579863-A2 | COMPOUNDS FOR TREATMENT OF BOVINE MASTITIS | Affinium Pharmaceuticals, Inc. (CA) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011156811-A2 | COMPOUNDS FOR TREATMENT OF BOVINE MASTITIS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2011-12-15 | — | — | WO | disclosed |