Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212572 | 0.87 | BRD4 (0.47) | MAOBFLT3CYP1A1CYP1B1BRD4 | |
| SCHEMBL725307 | 0.85 | PDE4C (0.54) | BRD4PDE4CJAK2JAK1TYK2 | |
| SCHEMBL722330 | 0.83 | RPS6KA2 (0.48) | CYP1A1CYP1B1BRD4PDE4CJAK2 | |
| SCHEMBL724918 | 0.83 | PDE4C (0.41) | CYP1A1CYP1B1BRD4PDE4CJAK2 | |
| SCHEMBL723093 | 0.82 | PDE4C (0.55) | CYP1A1CYP1B1BRD4PDE4CJAK2 | |
| SCHEMBL723294 | 0.82 | PDE4C (0.47) | CYP1A1CYP1B1PDE4CJAK2JAK1 | |
| SCHEMBL722573 | 0.82 | TERT (0.46) | CYP1A1CYP1B1BRD4IGF1RPDE4C | |
| SCHEMBL721960 | 0.81 | JAK2 (0.62) | CYP1A1CYP1B1IGF1RPIK3CAPDE4C | |
| SCHEMBL725083 | 0.81 | RPS6KA2 (0.41) | BRD4PDE4CJAK2JAK1TYK2 | |
| SCHEMBL15209738 | 0.81 | PDE4C (0.42) | CYP1A1CYP1B1BRD4PDE4CJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |