⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935460 | 0.94 | — | — | |
| SCHEMBL7693011 | 0.90 | THRB (0.31) | — | |
| SCHEMBL17433693 | 0.82 | — | — | |
| SCHEMBL29281938 | 0.76 | THRB (0.52) | — | |
| SCHEMBL9943482 | 0.76 | THRB (0.52) | — | |
| SCHEMBL28324142 | 0.76 | THRB (0.52) | — | |
| SCHEMBL1502755 | 0.76 | THRB (0.52) | — | |
| SCHEMBL830695 | 0.76 | THRB (0.52) | — | |
| SCHEMBL6562727 | 0.76 | THRB (0.52) | — | |
| SCHEMBL2785407 | 0.76 | THRB (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130156720-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLIC SYNDROME AND RELATED DISEASES AND DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130129660-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GASTROINTESTINAL DISORDERS AND GERD-RELATED RESPIRATORY DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| WO-2012027331-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLIC SYNDROME AND RELATED DISEASES AND DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20110129433-A1 | Compositions and Methods for Treating or Preventing Gastrointestinal Disorders and GERD-Related Respiratory Disorders | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| WO-2009158625-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GASTROINTESTINAL DISORDERS AND GERD-RELATED RESPIRATORY DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| US-6605270-B1 | Removing iron from patient by orally administering therapeutically effective amount of polymer characterized by specified repeat unit, or heteropolymer thereof | GENZYME CORPORATION | 2003-08-12 | — | — | US | disclosed |
| US-6060517-A | Process for removing bile salts from a patient and compositions therefor | GELTEX PHARMACEUTICALS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| US-5840766-A | Process for removing bile salts from a patient and compositions therefor | GELTEX PHARMACEUTICALS, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| US-5702696-A | FOR TREATMENT OF IRON OVERLOAD DISORDERS | GELTEX PHARMACEUTICALS (US) | 1997-12-30 | — | — | US | disclosed |
| US-5703188-A | Process for removing bile salts from a patient and compositions therefor | GELTEX PHARMACEUTICALS, INC. (US) | 1997-12-30 | — | — | US | disclosed |