SCHEMBL725638

SCHEMBL725638

O=C1c2ccccc2Cc2c[c]c3ccccc3c21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.52
CES1 P23141 2/20 0.44
BCHE P06276 1/20 0.44
ALDH1A1 P00352 5/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
MIF P14174 3/20 0.37
MAOB P27338 2/20 0.37
CYP19A1 P11511 2/20 0.37
TNF P01375 2/20 0.37
KDM4E B2RXH2 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
MAPT P10636 3/20 0.36
ACHE P22303 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP2 O95551 1/20 0.34
CASP3 P42574 1/20 0.34
CASP7 P55210 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29197402 0.87 MAOA (0.39) MAOACES1BCHEALDH1A1CYP2C19
SCHEMBL769934 0.74 MAOA (0.71) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL10703055 0.73 MAOA (0.59) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL23839 0.72 MAOA (0.57) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL10756250 0.71 MAOA (0.55) MAOACES1BCHEALDH1A1CYP1A2
Anthrone SCHEMBL18143 0.71 MAOA (1.00) MAOACES1BCHEALDH1A1CYP1A2
Anthrone SCHEMBL1527782 0.71 MAOA (1.00) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL2319027 0.71 MAOA (0.90) MAOACES1BCHEALDH1A1CYP1A2
Anthrone SCHEMBL29448801 0.71 MAOA (1.00) MAOACES1BCHEALDH1A1CYP1A2
Anthrone SCHEMBL29357010 0.71 MAOA (1.00) MAOACES1BCHEALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1670864-B1 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS SABIC INNOVATIVE PLASTICS IP (NL) 2012-02-29 EP claimed
EP-1670864-A2 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2006-06-21 EP claimed
US-6995266-B2 Thermally stable anthrapyridone compositions GENERAL ELECTRIC COMPANY (US) 2006-02-07 US claimed
WO-2005033210-A2 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2005-04-14 WO claimed
US-20050075500-A1 Thermally stable anthrapyridone compositions SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2005-04-07 US claimed
US-3972881-A VAT, CELLULOSE CIBA-GEIGY CORPORATION (US) 1976-08-03 US claimed
JP-3163459-A None JP disclosed
EP-1670864-B1 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS SABIC INNOVATIVE PLASTICS IP (NL) 2012-02-29 EP disclosed
US-7655085-B2 Such as 3'-phenyl-2-methyl-4(anthraquinoneamino)-1,9-anthrapyridone; useful as colorants in resin and are resistant to degradation and color shift when processed with resins at high temperatures SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-02-02 US disclosed
EP-1670864-A2 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2006-06-21 EP disclosed
US-20060106140-A1 Thermally stable anthrapyridone GENERAL ELECTRIC COMPANY (US) 2006-05-18 US disclosed
US-6995266-B2 Thermally stable anthrapyridone compositions GENERAL ELECTRIC COMPANY (US) 2006-02-07 US disclosed
WO-2005033210-A2 THERMALLY STABLE ANTHRAPYRIDONE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2005-04-14 WO disclosed
US-20050075500-A1 Thermally stable anthrapyridone compositions SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2005-04-07 US disclosed
JP-H03163459-A ELECTROPHOTOGRAPHIC SENSITIVE BODY AND ORIGINAL PRINTING PLATE FOR ELECTROPHOTOGRAPHIC PROCESS FUJI PHOTO FILM CO LTD 1991-07-15 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050075500-A1 Thermally stable anthrapyridone compositions IK, H1-0, H1-4 MAOA 2660/4885CES1 3740/4885BCHE 4558/4885
US-20060106140-A1 Thermally stable anthrapyridone IK, H1-0, H1-4 MAOA 2639/4885CES1 3731/4885BCHE 4520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.