Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 6/20 | 0.54 |
| ▸ | MAOB | P27338 | 6/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.52 |
| ▸ | RRM1 | P23921 | 1/20 | 0.51 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240497 | 0.81 | RAB9A (0.69) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7229929 | 0.81 | RAB9A (0.69) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7240624 | 0.80 | RAB9A (0.71) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL30581066 | 0.79 | RAB9A (0.78) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7239062 | 0.78 | RAB9A (1.00) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7239525 | 0.78 | RAB9A (0.86) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7235879 | 0.75 | RAB9A (0.64) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7256703 | 0.75 | RAB9A (0.70) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7258047 | 0.75 | RAB9A (0.70) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7238113 | 0.74 | RAB9A (0.76) | RAB9ANPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006443-A2 | 2- 4-(NAPHTALIN-2-YL)-THIAZOL-2-YLAMINOCARBONYL BENZOIC ACID AND 2- 4-(NAPHTALIN-2-YL)-PYRIMIDIN-2-YLAMINOCARBONYL BENZOIC ACID AND ADDITIONAL COMPOUNDS SERVING AS TELOMERASE INHIBITORS FOR USE IN TUMOR THERAPY | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-23 | — | — | WO | claimed |
| WO-2003006443-A2 | 2- 4-(NAPHTALIN-2-YL)-THIAZOL-2-YLAMINOCARBONYL BENZOIC ACID AND 2- 4-(NAPHTALIN-2-YL)-PYRIMIDIN-2-YLAMINOCARBONYL BENZOIC ACID AND ADDITIONAL COMPOUNDS SERVING AS TELOMERASE INHIBITORS FOR USE IN TUMOR THERAPY | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-23 | — | — | WO | disclosed |